One-pot chemoenzymatic synthesis of glycopolymers from unprotected sugars via glycosidase-catalysed glycosylation using triazinyl glycosides†
Abstract
Glycopolymers were successfully synthesised from unprotected sugars in aqueous media via a one-pot chemoenzymatic process of three reactions; the direct synthesis of 4,6-dimethoxy-1,3,5-triazin-2-yl glycosides from unprotected sugars, a glycosidase-catalysed glycosylation using the triazinyl glycoside to afford glycomonomers and a radical polymerisation. The resulting glycopolymers exhibited specific interactions with the corresponding lectin as glycoclusters.