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N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils

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Abstract

In this study, a series of organo difluoroboron probes with a BF2 benzamide moiety was designed, prepared and evaluated. Among them, 2c displayed the best optical and biological properties, and may be used as a useful near-infrared fluorescent probe for the detection of Aβ plaques and neurofibrillary tangles in AD.

Graphical abstract: N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils

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Article information


Submitted
18 Apr 2020
Accepted
21 May 2020
First published
21 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils

Y. Chen, C. Yuan, T. Xie, Y. Li, B. Dai, K. Zhou, Y. Liang, J. Dai, H. Tan and M. Cui, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02820G

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