Near-infrared fluorescent chemodosimeter for real-time in vivo evaluation of H2S-release efficiency of prodrug

Abstract

Hydrogen sulfide (H₂S) is a significant gasotransmitter. A deficiency in H₂S might contribute to some serious diseases. The development of H₂S drugs has received a great deal of attention. There is a pressing need for an effective method to evaluate H₂S release efficiency, especially in in vivo evaluation. In this study, a highly sensitive and selective near-infrared (NIR) fluorescent chemodosimeter (NRh-N₃) was synthesized for detecting H₂S. Importantly, NRh-N₃ was shown to be capable of visually monitoring H₂S-release from the prodrug in vitro and in vivo.