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Near-infrared fluorescent chemodosimeter for real-time in vivo evaluation of H2S-release efficiency of prodrug

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Abstract

Hydrogen sulfide (H2S) is a significant gasotransmitter. A deficiency in H2S might contribute to some serious diseases. The development of H2S drugs has received a great deal of attention. There is a pressing need for an effective method to evaluate H2S release efficiency, especially in in vivo evaluation. In this study, a highly sensitive and selective near-infrared (NIR) fluorescent chemodosimeter (NRh-N3) was synthesized for detecting H2S. Importantly, NRh-N3 was shown to be capable of visually monitoring H2S-release from the prodrug in vitro and in vivo.

Graphical abstract: Near-infrared fluorescent chemodosimeter for real-time in vivo evaluation of H2S-release efficiency of prodrug

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Supplementary files

Article information


Submitted
18 Apr 2020
Accepted
29 May 2020
First published
29 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Near-infrared fluorescent chemodosimeter for real-time in vivo evaluation of H2S-release efficiency of prodrug

X. Yao, W. Liu, W. Zhu, A. Tiemuer, F. Zhou, S. Yang, H. Yu, X. Qian and Y. Liu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02814B

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