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Nanoparticle–cell–nanoparticle communication by stigmergy to enhance poly(I:C) induced apoptosis in cancer cells

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Abstract

Nanoparticle–cell–nanoparticle communication by stigmergy was demonstrated using two capped nanodevices. The first community of nanoparticles (i.e. S(RA)IFN) is loaded with 9-cis-retinoic acid and capped with interferon-γ, whereas the second community of nanoparticles (i.e. S(sulf)PIC) is loaded with sulforhodamine B and capped with poly(I:C). The uptake of S(RA)IFN by SK-BR-3 breast cancer cells enhanced the expression of TLR3 receptor facilitating the subsequent uptake of S(sulf)PIC and cell killing.

Graphical abstract: Nanoparticle–cell–nanoparticle communication by stigmergy to enhance poly(I:C) induced apoptosis in cancer cells

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Supplementary files

Article information


Submitted
17 Apr 2020
Accepted
19 May 2020
First published
19 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Nanoparticle–cell–nanoparticle communication by stigmergy to enhance poly(I:C) induced apoptosis in cancer cells

A. Ultimo, C. de la Torre, C. Giménez, E. Aznar, C. Coll, M. D. Marcos, J. R. Murguía, R. Martínez-Máñez and F. Sancenón, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02795B

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