Two types of pyridoxal analogs, azido pyridoxal (PL-N3) and carboxyl pyridoxal (PL-COOH), were developed as novel bifunctional bioorthogonal molecules. These molecules showed fast imine formation with hydrazinyl groups and stable covalent linkages via azido/carboxyl groups, and thus were of great use for site-specific peptide and protein modifications.
X. Mao, W. Li, S. Zhu, J. Zou, H. Tian, Y. Duan, Y. Wang, J. Fei and X. Wang, Chem. Commun., 2020, 56, 7601 DOI: 10.1039/D0CC02722G
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