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Bifunctional pyridoxal derivatives as efficient bioorthogonal reagents for biomacromolecule modifications

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Abstract

Two types of pyridoxal analogs, azido pyridoxal (PL-N3) and carboxyl pyridoxal (PL-COOH), were developed as novel bifunctional bioorthogonal molecules. These molecules showed fast imine formation with hydrazinyl groups and stable covalent linkages via azido/carboxyl groups, and thus were of great use for site-specific peptide and protein modifications.

Graphical abstract: Bifunctional pyridoxal derivatives as efficient bioorthogonal reagents for biomacromolecule modifications

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Article information


Submitted
15 Apr 2020
Accepted
02 Jun 2020
First published
02 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Bifunctional pyridoxal derivatives as efficient bioorthogonal reagents for biomacromolecule modifications

X. Mao, W. Li, S. Zhu, J. Zou, H. Tian, Y. Duan, Y. Wang, J. Fei and X. Wang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02722G

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