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Mitochondriotropic Lanthanide Nanorods: Implications for Multimodal Imaging

Abstract

Mitochondria act as a prime therapeutic target for the treatment of various diseases and dysfunctional states. In this study, we have demonstrated the proof of concept of surface functionalization for achieving two-photon active mitochondriotropic lanthanide nanorods for higher resolution fluorescence imaging, and thereby, the spectral profile of mitochondria. The presence of Gd in the nanorods also enabled us to utilize this material as a T1-T2 dual-mode contrast reagent for recording magnetic resonance images of the mouse brain.

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Article information


Submitted
14 Apr 2020
Accepted
21 May 2020
First published
22 May 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Mitochondriotropic Lanthanide Nanorods: Implications for Multimodal Imaging

H. Singh, S. Sreedharan, E. Oyarzabal, T. Singha Mahapatra, N. Green, S. Yen-Yu Ian, M. Das, J. A. Thomas, S. K. Pramanik and A. Das, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC02698K

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