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Issue 57, 2020
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Controllable synthesis of 2- and 3-aryl-benzomorpholines from 2-aminophenols and 4-vinylphenols

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Abstract

We present herein a method for the controllable synthesis of 3-aryl-benzomorpholine and 2-aryl-benzomorpholine cycloadducts via cross-coupling/annulation between electron-rich 2-aminophenols and 4-vinylphenols. Molecular oxygen was successfully used in the reaction as the terminal oxidant and the complete inversion of chemoselectivity was achieved by the adjustment of the solvents and bases at room temperature.

Graphical abstract: Controllable synthesis of 2- and 3-aryl-benzomorpholines from 2-aminophenols and 4-vinylphenols

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Supplementary files

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Submitted
13 Apr 2020
Accepted
04 Jun 2020
First published
05 Jun 2020

Chem. Commun., 2020,56, 7941-7944
Article type
Communication

Controllable synthesis of 2- and 3-aryl-benzomorpholines from 2-aminophenols and 4-vinylphenols

K. Dong, X. Jin, S. Chen, L. Wu and Q. Liu, Chem. Commun., 2020, 56, 7941
DOI: 10.1039/D0CC02662J

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