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Cell organelle targeting of near-infrared croconaine dye controls photothermal outcome

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Abstract

Near-infrared croconaine–peptide conjugates that target the cell nucleus promote photothermal induced cell death. In contrast, a croconaine–morpholine conjugate that targets the cell lysosomes promotes lysosome permeabilization without measurable cell phototoxicity.

Graphical abstract: Cell organelle targeting of near-infrared croconaine dye controls photothermal outcome

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Article information


Submitted
10 Apr 2020
Accepted
15 May 2020
First published
15 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Cell organelle targeting of near-infrared croconaine dye controls photothermal outcome

Y. Wen, H. H. McGarraugh, C. L. Schreiber and B. D. Smith, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02612C

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