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Tuning the antimicrobial activity of low molecular weight hydrogels using dopamine autoxidation

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Abstract

We present a method to trigger the formation of dipeptide-based hydrogels by the simple addition of dopamine. Dopamine undergoes oxidation in air, reducing the pH to induce gelation. The production of polydopamine and release of reactive oxygen species such as hydrogen peroxide confers antimicrobial activity. Gel stiffness can be controlled by modulating the initial starting pH of the gelator solution. We can use this method to tune the antimicrobial activity of the gels, with gels that are less stiff demonstrating increased bactericidal efficacy against Gram-positive bacteria.

Graphical abstract: Tuning the antimicrobial activity of low molecular weight hydrogels using dopamine autoxidation

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Supplementary files

Article information


Submitted
09 Apr 2020
Accepted
10 Jun 2020
First published
10 Jun 2020

This article is Open Access

Chem. Commun., 2020, Advance Article
Article type
Communication

Tuning the antimicrobial activity of low molecular weight hydrogels using dopamine autoxidation

E. R. Cross, S. M. Coulter, A. M. Fuentes-Caparrós, K. McAulay, R. Schweins, G. Laverty and D. J. Adams, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02569K

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