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Three component hydroxyletherification and hydroxylazidation of (trifluoromethyl)alkenes: access to α-trifluoromethyl β-heteroatom substituted tertiary alcohols

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Abstract

The three component hydroxyletherification and hydroxylazidation reactions of (trifluoromethyl)alkenes are reported, providing various useful α-trifluoromethyl β-heteroatom substituted tertiary alcohols in high yields. The ipso-defluorooxylation of (trifluoromethyl)alkenes with oximes is completely inhibited. A pesticidal active compound could be synthesized with our method.

Graphical abstract: Three component hydroxyletherification and hydroxylazidation of (trifluoromethyl)alkenes: access to α-trifluoromethyl β-heteroatom substituted tertiary alcohols

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Article information


Submitted
08 Apr 2020
Accepted
28 Apr 2020
First published
29 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Three component hydroxyletherification and hydroxylazidation of (trifluoromethyl)alkenes: access to α-trifluoromethyl β-heteroatom substituted tertiary alcohols

H. Zeng, C. Zhu, C. Liu, Y. Cai, F. Chen and H. Jiang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02550J

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