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Biomineralized nanosilica-based organelles endow living yeast cells with non-inherent biological functions

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Abstract

We propose a biomimetic strategy to construct engineered yeast cells (EYCs) by building intracellular silica nanoscaffolds as biomimetic organelles. These nanosilica-based organelles can coordinate with loaded drug and yeast as a shell could prevent drug leakage. In vivo results show that EYCs serve as a dually responsive drug delivery system, targeted with extracellular caps (folate) and triggered by intracellular SiO2 at the low pH of cancer tissue.

Graphical abstract: Biomineralized nanosilica-based organelles endow living yeast cells with non-inherent biological functions

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Article information


Submitted
08 Apr 2020
Accepted
15 Apr 2020
First published
15 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Biomineralized nanosilica-based organelles endow living yeast cells with non-inherent biological functions

Y. Chang, T. Liu, P. Liu, L. Meng, S. Li, Y. Guo, L. Yang and X. Ma, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02546A

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