Issue 58, 2020

Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA

Abstract

A rationally designed mannosylated amphiphilic pillar[5]arene (Man@AP5) self-assembles into supramolecular vesicles with encapsulated vancomycin (Man@AP5-Van), which target macrophages, respond to both acid and cathepsin B, and release vancomycin (Van) rapidly inside macrophages. Man@AP5-Van significantly increases the intracellular concentration of Van, enhancing its antibacterial efficacy against intracellular MRSA.

Graphical abstract: Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA

Supplementary files

Article information

Article type
Communication
Submitted
08 Apr 2020
Accepted
01 Jun 2020
First published
12 Jun 2020

Chem. Commun., 2020,56, 8115-8118

Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA

H. Peng, B. Xie, X. Yang, J. Dai, G. Wei and Y. He, Chem. Commun., 2020, 56, 8115 DOI: 10.1039/D0CC02522D

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