Issue 58, 2020
From the journal:

Chemical Communications

Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA†

Haibo Peng,‡a   Beibei Xie, ORCID logo ‡a   Xiaohong Yang,b   Jiaojiao Dai,a   Guoxing Weia  and  Yun He ORCID logo *a  

* Corresponding authors

a Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, 55 Daxuecheng South Road, 401331 Shapingba, Chongqing, China
E-mail: yun.he@cqu.edu.cn

b Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, 266 Fangzheng Ave, ShuiTu Technology Development Zone, Beibei District, Chongqing, China

Abstract

A rationally designed mannosylated amphiphilic pillar[5]arene (Man@AP5) self-assembles into supramolecular vesicles with encapsulated vancomycin (Man@AP5-Van), which target macrophages, respond to both acid and cathepsin B, and release vancomycin (Van) rapidly inside macrophages. Man@AP5-Van significantly increases the intracellular concentration of Van, enhancing its antibacterial efficacy against intracellular MRSA.

Graphical abstract: Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA

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Article information

DOI
https://doi.org/10.1039/D0CC02522D
Article type
Communication
Submitted
08 Apr 2020
Accepted
01 Jun 2020
First published
12 Jun 2020

Chem. Commun., 2020,56, 8115-8118

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Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA

H. Peng, B. Xie, X. Yang, J. Dai, G. Wei and Y. He, Chem. Commun., 2020, 56, 8115 DOI: 10.1039/D0CC02522D

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