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Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA

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Abstract

A rationally designed mannosylated amphiphilic pillar[5]arene (Man@AP5) self-assembles into supramolecular vesicles with encapsulated vancomycin (Man@AP5-Van), which target macrophages, respond to both acid and cathepsin B, and release vancomycin (Van) rapidly inside macrophages. Man@AP5-Van significantly increases the intracellular concentration of Van, enhancing its antibacterial efficacy against intracellular MRSA.

Graphical abstract: Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA

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Supplementary files

Article information


Submitted
08 Apr 2020
Accepted
01 Jun 2020
First published
12 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA

H. Peng, B. Xie, X. Yang, J. Dai, G. Wei and Y. He, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02522D

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