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NO release regulated by doxorubicin as the green light-harvesting antenna

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Abstract

We report for the first time a NO photodonor (NOPD) operating with the widely used chemotherapeutic agent doxorubicin (DOX) as the light-harvesting antenna. This permits NO uncaging from an N-nitroso appendage upon selective excitation of DOX with highly biocompatible green light, without precluding its typical red emission. This NOPD effectively binds DNA and photodelivers NO nearby, representing an intriguing candidate for potential multimodal therapeutic applications based on the combination of DOX and NO.

Graphical abstract: NO release regulated by doxorubicin as the green light-harvesting antenna

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Article information


Submitted
07 Apr 2020
Accepted
12 May 2020
First published
12 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

NO release regulated by doxorubicin as the green light-harvesting antenna

A. Fraix, C. Parisi, M. Failla, K. Chegaev, F. Spyrakis, L. Lazzarato, R. Fruttero, A. Gasco and S. Sortino, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02512G

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