Issue 47, 2020
From the journal:

Chemical Communications

NO release regulated by doxorubicin as the green light-harvesting antenna†

Aurore Fraix, ORCID logo ‡a   Cristina Parisi, ORCID logo ‡a   Mariacristina Failla, ORCID logo ‡ab   Konstantin Chegaev, ORCID logo b   Francesca Spyrakis, ORCID logo b   Loretta Lazzarato, ORCID logo *b   Roberta Fruttero, ORCID logo b   Alberto Gascob  and  Salvatore Sortino ORCID logo *a  

* Corresponding authors

a PhotoChemLab, Department of Drug Sciences, University of Catania, 95125 Catania, Italy
E-mail: ssortino@unict.it

b Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy
E-mail: loretta.lazzarato@unito.it

Abstract

We report for the first time a NO photodonor (NOPD) operating with the widely used chemotherapeutic agent doxorubicin (DOX) as the light-harvesting antenna. This permits NO uncaging from an N-nitroso appendage upon selective excitation of DOX with highly biocompatible green light, without precluding its typical red emission. This NOPD effectively binds DNA and photodelivers NO nearby, representing an intriguing candidate for potential multimodal therapeutic applications based on the combination of DOX and NO.

Graphical abstract: NO release regulated by doxorubicin as the green light-harvesting antenna

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Article information

DOI
https://doi.org/10.1039/D0CC02512G
Article type
Communication
Submitted
07 Apr 2020
Accepted
12 May 2020
First published
12 May 2020

Chem. Commun., 2020,56, 6332-6335

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NO release regulated by doxorubicin as the green light-harvesting antenna

A. Fraix, C. Parisi, M. Failla, K. Chegaev, F. Spyrakis, L. Lazzarato, R. Fruttero, A. Gasco and S. Sortino, Chem. Commun., 2020, 56, 6332 DOI: 10.1039/D0CC02512G

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