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Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia

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Abstract

We synthesized all major saturated and unsaturated 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia, quantified their native production levels and characterized their antibiotic activities against competing Staphylococcus aureus. We demonstrate that quinolone core methylation and position of unsaturation in the alkyl-chain dictate antibiotic potency which supports the proposed mechanism of action.

Graphical abstract: Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia

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Article information


Submitted
07 Apr 2020
Accepted
15 May 2020
First published
15 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia

D. Szamosvári, M. Prothiwa, C. L. Dieterich and T. Böttcher, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02498H

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