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X-Ray fluorescence microscopy reveals that rhenium(i) tricarbonyl isonitrile complexes remain intact in vitro

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Abstract

The complex fac-[Re(CO)3(dmphen)(para-tolylisonitrile)]+ (TRIP), where dmphen = 2,9-dimethyl-1,10-phenanthroline, is an endoplasmic reticulum stress-inducing anticancer agent (A. P. King, S. C. Marker, R. V. Swanda, J. J. Woods, S.-B. Qian and J. J. Wilson, Chem. – Eur. J., 2019, 25, 9206–9210). A second-generation compound fac-[Re(CO)3(dmphen)(para-iodobenzeneisonitrile)]+ (I-TRIP) was synthesized, and its intracellular distribution was investigated using X-ray fluorescence microscopy to show that these complexes are highly stable in vitro.

Graphical abstract: X-Ray fluorescence microscopy reveals that rhenium(i) tricarbonyl isonitrile complexes remain intact in vitro

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Article information


Submitted
04 Apr 2020
Accepted
05 May 2020
First published
20 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

X-Ray fluorescence microscopy reveals that rhenium(I) tricarbonyl isonitrile complexes remain intact in vitro

C. C. Konkankit, J. Lovett, H. H. Harris and J. J. Wilson, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02451A

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