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Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds

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Abstract

Functionalised triazole aldehydes are used in the highly selective self-assembly of water-compatible, optically pure, low symmetry Fe(II)- and Zn(II)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.

Graphical abstract: Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds

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Article information


Submitted
03 Apr 2020
Accepted
29 Apr 2020
First published
29 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds

H. Song, N. J. Rogers, V. Brabec, G. J. Clarkson, J. P. C. Coverdale, H. Kostrhunova, R. M. Phillips, M. Postings, S. L. Shepherd and P. Scott, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02429E

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