Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Atroposelective synthesis of configurationally stable nonbiaryl N–C atropisomers through direct asymmetric aminations of 1,3-benzenediamines

Author affiliations

Abstract

A highly atroposelective synthesis of nonbiaryl N–C atropisomers was achieved via direct aminations of 1,3-benzenediamines with azodicarboxylates enabled by chiral phosphoric acid catalysis. A series of N-substituents, benzene-substituents and azodicarboxylates were well tolerated, generating N–C atropisomers with high configurational stability. The facile derivatizations and utilizations of the chiral products as novel chiral organocatalysts demonstrate the value of these reactions.

Graphical abstract: Atroposelective synthesis of configurationally stable nonbiaryl N–C atropisomers through direct asymmetric aminations of 1,3-benzenediamines

Back to tab navigation

Supplementary files

Article information


Submitted
02 Apr 2020
Accepted
24 Apr 2020
First published
24 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Atroposelective synthesis of configurationally stable nonbiaryl N–C atropisomers through direct asymmetric aminations of 1,3-benzenediamines

D. Wang, Q. Jiang and X. Yang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02368J

Social activity

Search articles by author

Spotlight

Advertisements