Issue 52, 2020
From the journal:

Chemical Communications

Dehydroxyalkylative halogenation of C(aryl)–C bonds of aryl alcohols†

Mingyang Liu, ORCID logo abc   Zhanrong Zhang, ORCID logo *ac   Huizhen Liu, ORCID logo abc   Tianbin Wu ORCID logo ab  and  Buxing Han ORCID logo *abc  

* Corresponding authors

a Beijing National Laboratory for Molecular Science, CAS Key Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: zhangzhanrong@iccas.ac.cn, hanbx@iccas.ac.cn

b School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

c Physical Science Laboratory, Huairou National Comprehensive Science Center, No. 5 Yanqi East Second Street, Beijing 101400, China

Abstract

We herein report Cu mediated side-directed dehydroxyalkylative halogenation of aryl alcohols. C(aryl)–C bonds of aryl alcohols were effectively cleaved, affording the corresponding aryl chlorides, bromides and iodides in excellent yields. Aryl alcohols could serve as both aromatic electrophilic and radical synthetic equivalents during the reaction.

Graphical abstract: Dehydroxyalkylative halogenation of C(aryl)–C bonds of aryl alcohols

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Article information

DOI
https://doi.org/10.1039/D0CC02306J
Article type
Communication
Submitted
30 Mar 2020
Accepted
19 May 2020
First published
19 May 2020

Chem. Commun., 2020,56, 7120-7123

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Dehydroxyalkylative halogenation of C(aryl)–C bonds of aryl alcohols

M. Liu, Z. Zhang, H. Liu, T. Wu and B. Han, Chem. Commun., 2020, 56, 7120 DOI: 10.1039/D0CC02306J

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