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Monitoring protein ubiquitination and SUMOylation in real-time by NMR

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Abstract

The covalent conjugation of ubiquitin (Ub), known as ubiquitination, is a multi-step reaction involving multiple enzymes. We report a real-time, tag-free method to monitor protein ubiquitination by NMR spectroscopy under physiological conditions. The approach is also applicable for monitoring other ubiquitin-like modifications, and the disassembly of Ub polymers.

Graphical abstract: Monitoring protein ubiquitination and SUMOylation in real-time by NMR

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Article information


Submitted
30 Mar 2020
Accepted
06 May 2020
First published
08 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Monitoring protein ubiquitination and SUMOylation in real-time by NMR

B. I. Habibullah, V. Tripathi, P. Surana and R. Das, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02252G

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