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Regioselective Synthesis and Anticancer Evaluation of H2O2-Activatable Nucleosides

Abstract

We describe here the design, synthesis, and biological evaluation of H2O2-activatable nucleosides via an efficient and regioselective functionalization of unprotected precursors. Biological evaluation of H2O2-specific responsive prodrug of gemecitabin demonstrates an extremenly fast activation, low toxicity and enhanced anticancer effects in two cell lines.

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Supplementary files

Article information


Submitted
27 Mar 2020
Accepted
18 May 2020
First published
18 May 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Regioselective Synthesis and Anticancer Evaluation of H2O2-Activatable Nucleosides

Y. Sun, L. Liu and L. Cheng, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC02245D

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