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ArnD is a deformylase involved in polymyxin resistance

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Abstract

The modification of lipid A with cationic 4-amino-4-deoxy-L-arabinose residues serves to confer resistance against cationic peptide antibiotics in Gram-negative bacteria. In this work, the enzyme ArnD is shown to act as a metal-dependent deformylase in the biosynthesis of this carbohydrate.

Graphical abstract: ArnD is a deformylase involved in polymyxin resistance

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Article information


Submitted
27 Mar 2020
Accepted
13 May 2020
First published
13 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

ArnD is a deformylase involved in polymyxin resistance

T. Adak, D. L. Morales, A. J. Cook, J. C. Grigg, M. E. P. Murphy and M. E. Tanner, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02241A

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