Issue 74, 2020
From the journal:

Chemical Communications

Bacteria mimics bearing carbohydrates, oligodeoxynucleotides and designed shapes†

Jun Hu,‡a   Yan Gu,‡b   Mengjie Liu,a   Weidong Zhang, ORCID logo *a   Hong Chen ORCID logo b  and  Gaojian Chen ORCID logo *ab  

* Corresponding authors

a Center for Soft Condensed Matter Physics and Interdisciplinary Research and School of Physical Science and Technology, Soochow University, Suzhou 215006, P. R. China
E-mail: gchen@suda.edu.cn

b State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China

Abstract

We utilize a facile and gentle strategy to fabricate bacteria mimics (“bacillus” and “coccus”) endowed with carbohydrates, oligodeoxynucleotides and designed shapes via dopamine-polymer based nanoparticle fabrication and DNA-based multivalent interactions. These bacteria mimics with TLR- and CLR-targeted capabilities are demonstrated to exhibit enhanced immune stimulating efficiency.

Graphical abstract: Bacteria mimics bearing carbohydrates, oligodeoxynucleotides and designed shapes

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Article information

DOI
https://doi.org/10.1039/D0CC02239J
Article type
Communication
Submitted
27 Mar 2020
Accepted
18 May 2020
First published
18 May 2020

Chem. Commun., 2020,56, 10887-10889

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Bacteria mimics bearing carbohydrates, oligodeoxynucleotides and designed shapes

J. Hu, Y. Gu, M. Liu, W. Zhang, H. Chen and G. Chen, Chem. Commun., 2020, 56, 10887 DOI: 10.1039/D0CC02239J

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