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Hg−C Bond Protonolysis by A Functional Model of Bacterial Enzyme Organomercurial Lyase MerB

Abstract

Herein, we report a novel synthetic compound ImMeSePrSH, having a highly nucleophilic selenolate (Se) moiety and a thiol (-SH) functional group, which showed efficient Hg–C bond protonolysis of various R–Hg–X molecules including neurotoxic methylmercury and thimerosal, via direct -SH proton transfer to highly activated C-atom of departed R group with low activation energy barrier at room temperature (21 οC), in the absence of any external proton source and, thus, acts as a functional model of MerB.

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Article information


Submitted
29 Mar 2020
Accepted
20 May 2020
First published
20 May 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Hg−C Bond Protonolysis by A Functional Model of Bacterial Enzyme Organomercurial Lyase MerB

G. Roy, R. Karri, R. Das, R. K. Rai and A. Gopalakrishnan, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC02232B

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