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Issue 45, 2020
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Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer–protein interactions

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Abstract

An aldehyde acrylate-based functional monomer was incorporated into poly(N-isopropylacrylamide-co-methacrylic acid) nanogels for use as protein receptors. The aldehyde component forms dynamic imines with surface exposed lysine residues, while carboxylic acid/carboxylate moieties form electrostatic interactions with high isoelectric point proteins. Together, these interactions effect protein adsorption and recognition.

Graphical abstract: Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer–protein interactions

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Supplementary files

Article information


Submitted
27 Mar 2020
Accepted
28 Apr 2020
First published
28 Apr 2020

Chem. Commun., 2020,56, 6141-6144
Article type
Communication

Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer–protein interactions

M. E. Wechsler, H. K. H. J. Dang, S. D. Dahlhauser, S. P. Simmonds, J. F. Reuther, J. M. Wyse, A. N. VandeWalle, E. V. Anslyn and N. A. Peppas, Chem. Commun., 2020, 56, 6141
DOI: 10.1039/D0CC02200D

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