Issue 45, 2020

Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer–protein interactions

Abstract

An aldehyde acrylate-based functional monomer was incorporated into poly(N-isopropylacrylamide-co-methacrylic acid) nanogels for use as protein receptors. The aldehyde component forms dynamic imines with surface exposed lysine residues, while carboxylic acid/carboxylate moieties form electrostatic interactions with high isoelectric point proteins. Together, these interactions effect protein adsorption and recognition.

Graphical abstract: Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer–protein interactions

Supplementary files

Article information

Article type
Communication
Submitted
27 Mar 2020
Accepted
28 Apr 2020
First published
28 Apr 2020

Chem. Commun., 2020,56, 6141-6144

Author version available

Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer–protein interactions

M. E. Wechsler, H. K. H. J. Dang, S. D. Dahlhauser, S. P. Simmonds, J. F. Reuther, J. M. Wyse, A. N. VandeWalle, E. V. Anslyn and N. A. Peppas, Chem. Commun., 2020, 56, 6141 DOI: 10.1039/D0CC02200D

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