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Chemically synthesized circular RNAs with phosphoramidate linkages enable rolling circle translation

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Abstract

Circular RNA without a stop codon enables rolling circle translation. To produce circular RNAs, we carried out one-pot chemical synthesis of circular RNA from RNA fragments with the use of an EDC/HOBt-based chemical ligation reaction. The synthesized circular RNAs acted as translation templates, despite the presence of unnatural phosphoramidate linkages.

Graphical abstract: Chemically synthesized circular RNAs with phosphoramidate linkages enable rolling circle translation

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Article information


Submitted
23 Mar 2020
Accepted
17 Apr 2020
First published
21 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Chemically synthesized circular RNAs with phosphoramidate linkages enable rolling circle translation

K. Nakamoto, N. Abe, G. Tsuji, Y. Kimura, F. Tomoike, Y. Shimizu and H. Abe, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02140G

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