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Issue 43, 2020
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Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

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Abstract

Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9. Recruitment of caspase-9 to the nanoscaffold results in an increase in enzymatic activity due to enhanced proximity, with a bell-shaped response as a function of nanoscaffold concentration. The modularity of the system allows for dynamic regulation of enzyme activity through variation of the recruitment-motif density along the supramolecular polymer.

Graphical abstract: Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

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Article information


Submitted
22 Mar 2020
Accepted
13 Apr 2020
First published
14 Apr 2020

This article is Open Access

Chem. Commun., 2020,56, 5747-5750
Article type
Communication

Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

E. Magdalena Estirado, B. J. H. M. Rosier, T. F. A. de Greef and L. Brunsveld, Chem. Commun., 2020, 56, 5747
DOI: 10.1039/D0CC02120B

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