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A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1–3Gal epitope

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Abstract

A double conjugation strategy was implemented to produce an anti-fentanyl vaccine, which was predicated upon preformed-antibody-assisted antigen presentation. The new vaccine was found to reduce the psychoactive effects of fentanyl without the addition of the immunostimulant CpG oligodeoxynucleotide.

Graphical abstract: A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1–3Gal epitope

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Article information


Submitted
22 Mar 2020
Accepted
03 May 2020
First published
04 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1–3Gal epitope

J. Wang, B. Ellis, B. Zhou, L. M. Eubanks, S. Blake and K. D. Janda, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02107E

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