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Benzeneselenol-modified gold nanoclusters for cancer therapy

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Abstract

We report benzeneselenol-modified gold nanoclusters (Se_Au NCs) that have significant anticancer activity by inducing autophagy and disassembly of F-actin in cancer cells. Upon treatment of different tumor models on mice, it has been found that Se_Au NCs exhibit excellent antitumor efficacy, high stability, and extremely low toxicity, which are the requirements for an ideal antineoplastic drug. Our study is a successful attempt in exploring novel anticancer agents with high biosafety.

Graphical abstract: Benzeneselenol-modified gold nanoclusters for cancer therapy

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Article information


Submitted
20 Mar 2020
Accepted
23 Apr 2020
First published
23 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Benzeneselenol-modified gold nanoclusters for cancer therapy

L. Wang, W. Zheng and X. Jiang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02077J

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