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An Accurate and Ultrasensitive SERS Sensor with Au-Se Interface for Bioimaging and in situ Quantitation

Abstract

SERS is valuable for high-sensitive and accurate bioimaging and molecule quantification. Generally for biological research, the SERS reporter molecules are connected to Au substrate for signal enhancement by Au-sulfur (Au-S) bonding. However, the extensive Au-S interface inevitably encounters with distortion by high levels of biothiols, leading to low sensitivity and false positive results. Here, we propose a kind of SERS nanoprobes with Au-selenol (Au-Se) interface for bioimaging. Compared with the Au-S SERS nanoprobes, Au-Se SERS nanoprobes show excellent stability in millimolar levels of GSH owing to higher bonding energy, and higher sensitivity due to greater chemical enhancement through Au-Se bonds. We further achieved in situ absolute quantitation of biomoleculers by ratio SERS analysis. The Au-Se SERS nanoprobes have supplied an ideal solution for accurate bioimaging and in situ quantitation.

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Supplementary files

Article information


Submitted
10 Apr 2020
Accepted
28 Jun 2020
First published
30 Jun 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

An Accurate and Ultrasensitive SERS Sensor with Au-Se Interface for Bioimaging and in situ Quantitation

X. Li, X. Duan, L. Li, S. Ye and B. Tang, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC02068K

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