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A mitochondrion-targeting Mn(ii)-terpyridine complex for two-photon photodynamic therapy

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Abstract

We developed a mitochondrion-targeting MnII-terpyridine complex (MTP) for two-photon photodynamic therapy. MTP was subjected to two-photon excitation in the NIR region to generate 1O2 and hence produce a PDT effect. This use of MTP overcame the drawbacks of traditional PDT agents. The MnII center of MTP apparently catalyzed the H2O2-mediated production of ROS and oxygen, which subsequently promoted the 1O2 generation, furthering the PDT effect. Additionally, the mitochondrion targeting of MTP provided a good spatial condition for the generation of 1O2, which further promoted the PDT effect.

Graphical abstract: A mitochondrion-targeting Mn(ii)-terpyridine complex for two-photon photodynamic therapy

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Supplementary files

Article information


Submitted
20 Mar 2020
Accepted
25 Jun 2020
First published
26 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A mitochondrion-targeting Mn(II)-terpyridine complex for two-photon photodynamic therapy

X. Yang, D. Zhang, J. Li, W. Ji, N. Yang, S. Gu, Q. Wu, Q. Jiang, P. Shi and L. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02051F

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