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Issue 43, 2020
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Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters

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Abstract

An ambident electrophilicity of phosphinic acid thioesters is disclosed. Unexpected carbon–sulfur bond formation took place in the reaction between phosphinic acid thioesters and benzyl Grignard reagents. The developed method for benzyl sulfides has a wide substrate scope and was applicable for the synthesis of a drug analog.

Graphical abstract: Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters

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Supplementary files

Article information


Submitted
19 Mar 2020
Accepted
16 Apr 2020
First published
16 Apr 2020

Chem. Commun., 2020,56, 5771-5774
Article type
Communication

Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters

Y. Nishiyama, T. Hosoya and S. Yoshida, Chem. Commun., 2020, 56, 5771
DOI: 10.1039/D0CC02039G

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