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Issue 43, 2020
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A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

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Abstract

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state. This theranostic molecule can be activated by nitroreductase under mild hypoxia to be used in fluorescence imaging and highly efficient photodynamic therapy (PDT) both in 2D and 3D (spheroids) HeLa cell culture models.

Graphical abstract: A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

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Supplementary files

Article information


Submitted
18 Mar 2020
Accepted
14 Apr 2020
First published
15 Apr 2020

Chem. Commun., 2020,56, 5819-5822
Article type
Communication

A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

J. Zheng, Y. Liu, F. Song, L. Jiao, Y. Wu and X. Peng, Chem. Commun., 2020, 56, 5819
DOI: 10.1039/D0CC02019B

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