Issue 94, 2020

Development of potent inhibitors for strigolactone receptor DWARF 14

Abstract

Strigolactones (SLs) are plant hormones that suppress shoot branching through perception by their receptor protein DWARF 14 (D14). The artificial regulation of SL signaling has been considered a potent agricultural technique because plant architecture is strongly related to crop yield. In this communication, we describe the development of a small-molecule D14 inhibitor that functions at sub-micromolar levels. This potent inhibitor may be a lead compound for a first-in-class plant growth regulator.

Graphical abstract: Development of potent inhibitors for strigolactone receptor DWARF 14

Supplementary files

Article information

Article type
Communication
Submitted
17 Mar 2020
Accepted
26 Oct 2020
First published
16 Nov 2020

Chem. Commun., 2020,56, 14917-14919

Author version available

Development of potent inhibitors for strigolactone receptor DWARF 14

M. Yoshimura, S. F. Kim, R. Takise, S. Kusano, S. Nakamura, M. Izumi, A. Yagi, K. Itami and S. Hagihara, Chem. Commun., 2020, 56, 14917 DOI: 10.1039/D0CC01989E

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