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Introducing aldehyde functionality to proteins using ligand-directed affinity labeling

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Abstract

Aldehyde is a versatile chemical handle for protein modification. Although many methods have been developed to label proteins with aldehyde, target-specific methods amenable to endogenous proteins are limited. Here, we report a simple affinity probe strategy to introduce aldehydes to native proteins. Notably, the probe contains a latent aldehyde functionality that is only exposed upon target binding, thereby enabling a one-pot labeling procedure.

Graphical abstract: Introducing aldehyde functionality to proteins using ligand-directed affinity labeling

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Article information


Submitted
16 Mar 2020
Accepted
22 Apr 2020
First published
23 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Introducing aldehyde functionality to proteins using ligand-directed affinity labeling

Y. Song, F. Xiong, J. Peng, Y. M. E. Fung, Y. Huang and X. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01982H

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