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Rapid sub-micromolar amperometric enzyme biosensing with free substrate access but without nanomaterial signalling support: oxidase-based glucose detection as a proof-of-principle example

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Abstract

High-sensitivity electrochemical glucose biosensing has so far been possible only through incorporation of nanomaterials into the glucose oxidase-(GOx) containing polymer layer on the detector surface. Here, as a conceptionally novel simplified option, pure gelatin thin films with covalently attached GOx were used to convert platinum (Pt) disk electrodes into rapidly responding amperometric glucose probes with a sub-micromolar limit of detection. The advanced enzymatic tools are easy to make and, as is crucial for a focus on waste minimization, green and sustainable, through restriction of sensor modification to readily available economical materials.

Graphical abstract: Rapid sub-micromolar amperometric enzyme biosensing with free substrate access but without nanomaterial signalling support: oxidase-based glucose detection as a proof-of-principle example

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Article information


Submitted
16 Mar 2020
Accepted
20 May 2020
First published
21 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Rapid sub-micromolar amperometric enzyme biosensing with free substrate access but without nanomaterial signalling support: oxidase-based glucose detection as a proof-of-principle example

K. Sakdaphetsiri, T. Thaweeskulchai and A. Schulte, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01976C

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