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An enzyme-free amplification strategy based on two-photon fluorescent carbon dots for monitoring miR-9 in live neurons and brain tissues of Alzheimer's disease mice

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Abstract

An enzyme-free amplification strategy based on two-photon fluorescent carbon dots for monitoring miR-9 in live neurons and brain tissues of Alzheimer's disease (AD) mice. Notably, using our developed probe, miR-9 was found to be up-regulated in early onset AD, while it was found to be down regulated to lower than the normal level in late onset AD.

Graphical abstract: An enzyme-free amplification strategy based on two-photon fluorescent carbon dots for monitoring miR-9 in live neurons and brain tissues of Alzheimer's disease mice

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Article information


Submitted
16 Mar 2020
Accepted
04 Jun 2020
First published
05 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

An enzyme-free amplification strategy based on two-photon fluorescent carbon dots for monitoring miR-9 in live neurons and brain tissues of Alzheimer's disease mice

W. Wu, T. Zheng and Y. Tian, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01971B

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