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Issue 53, 2020
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Calixarene-mediated assembly of water-soluble C60-attached ultrathin graphite hybrids for efficient activation of reactive oxygen species to treat neuroblastoma cells

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Abstract

Unprecedented nano-carbon hybrids consisting of exfoliated ultrathin graphite (or single-walled carbon nanotubes) with pristine C60 molecules attached on the surfaces have been produced in water in the presence of p-phosphonic acid calix[8]arene. The amphiphilic calixarene plays multiple roles in these processes to provide water dispersibility and π–π interactions with flexible conformations complementing curvatures of the carbon surfaces. The significantly increased water solubility and area of exposure of C60 enable efficient activation of reactive oxygen species for enhanced phototoxicity to SH-SY5Y human neuroblastoma cell line under laser irradiation.

Graphical abstract: Calixarene-mediated assembly of water-soluble C60-attached ultrathin graphite hybrids for efficient activation of reactive oxygen species to treat neuroblastoma cells

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Supplementary files

Article information


Submitted
13 Mar 2020
Accepted
26 May 2020
First published
27 May 2020

Chem. Commun., 2020,56, 7325-7328
Article type
Communication

Calixarene-mediated assembly of water-soluble C60-attached ultrathin graphite hybrids for efficient activation of reactive oxygen species to treat neuroblastoma cells

J. Mo, M. Li, X. Chen and Q. Li, Chem. Commun., 2020, 56, 7325
DOI: 10.1039/D0CC01921F

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