[3+1+1] type cyclization of ClCF2COONa for the assembly of imidazoles and tetrazoles via in situ generated isocyanides

Ya Wang; Yao Zhou; Qiuling Song

doi:10.1039/D0CC01919D

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[3+1+1] type cyclization of ClCF₂COONa for the assembly of imidazoles and tetrazoles via in situ generated isocyanides†

Ya Wang,^a Yao Zhou

^b and Qiuling Song

*^ac

Author affiliations

* Corresponding authors

^a Institute of Next Generation Matter Transformation, College of Materials Science & Engineering at Huaqiao University, 668 Jimei Blvd, Xiamen, Fujian, P. R. China
E-mail: qsong@hqu.edu.cn
Fax: +86-592-6162990

^b College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, Hubei, P. R. China

^c Fujian University Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, Fujian, China

Abstract

A facile synthesis of imidazoles and tetrazoles via [3+1+1] type cyclization of ClCF₂COONa is developed. A diverse array of imidazoles and tetrazoles were obtained in decent yields via isocyanide intermediates. Notably, this is the first example of the cycloaddition of in situ generated isocyanides.

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Article information

DOI: https://doi.org/10.1039/D0CC01919D
Article type: Communication
Submitted: 13 Mar 2020
Accepted: 20 Apr 2020
First published: 20 Apr 2020

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Chem. Commun., 2020,56, 6106-6109

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[3+1+1] type cyclization of ClCF₂COONa for the assembly of imidazoles and tetrazoles via in situ generated isocyanides

Y. Wang, Y. Zhou and Q. Song, Chem. Commun., 2020, 56, 6106 DOI: 10.1039/D0CC01919D

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