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Harnessing chemical exchange: 19F magnetic resonance OFF/ON zinc sensing with a Tm(iii) complex

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Abstract

A fluorinated, thulium(III) complex (Tm-PFZ-1) serves as an off–on 19F magnetic resonance probe for Zn(II). Rapid exchange among different conformations combined with paramagnetic relaxation and chemical shift effects of Tm(III) effectively eliminate the 19F NMR/MRI signal in Tm-PFZ-1. Chelation of Zn(II) induces increased structural rigidity and reduces exchange rate, affording a robust 19F NMR/MRI signal. Tm-PFZ-1 represents a first-in-class paramagnetic 19F MR agent that exploits a novel sensing mechanism for Zn(II) and is the first 19F MR-based scaffold to provide an “off–on” response to Zn(II) in aqueous solution.

Graphical abstract: Harnessing chemical exchange: 19F magnetic resonance OFF/ON zinc sensing with a Tm(iii) complex

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Article information


Submitted
11 Mar 2020
Accepted
24 Apr 2020
First published
24 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Harnessing chemical exchange: 19F magnetic resonance OFF/ON zinc sensing with a Tm(III) complex

M. Yu, D. Xie, R. T. Kadakia, W. Wang and E. L. Que, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01876G

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