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Deep imaging for visualizing nitric oxide in lipid droplets: discovering the relationship between nitric oxide and resistance to cancer chemotherapy drugs

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Abstract

A near-infrared two-photon fluorescent probe (TAN) was synthesized for selective detection and deep-depth imaging of NO in lipid droplets. All results demonstrated that NO production in lipid droplets is closely correlated with the resistance to anti-tumor drugs, and NO inhibitors can effectively improve the efficacy of chemotherapeutic agents.

Graphical abstract: Deep imaging for visualizing nitric oxide in lipid droplets: discovering the relationship between nitric oxide and resistance to cancer chemotherapy drugs

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Article information


Submitted
11 Mar 2020
Accepted
24 Apr 2020
First published
24 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Deep imaging for visualizing nitric oxide in lipid droplets: discovering the relationship between nitric oxide and resistance to cancer chemotherapy drugs

M. Ye, W. Hu, M. He, C. Li, S. Zhai, Z. Liu, Y. Wang, H. Zhang and C. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01856B

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