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Guanine anchoring: a strategy for specific targeting of a G-quadruplex using short PNA, LNA and DNA molecules

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Abstract

Two separate structural elements of a G-quadruplex (G4), a vacant site and a flanking single-strand, provide an opportunity for specific targeting of a particular G4 structure via dual recognition. Here, we show that a short peptide nucleic acid (PNA) can specifically recognize and bind to a G4 at sub-micromolar affinity based on both G-tetrad vacant site filling and complementary duplex formation. This sequence-guided guanine-anchoring strategy can be further developed for specific targeting of G4 structures using short DNA, LNA and PNA strands.

Graphical abstract: Guanine anchoring: a strategy for specific targeting of a G-quadruplex using short PNA, LNA and DNA molecules

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Article information


Submitted
07 Mar 2020
Accepted
16 Apr 2020
First published
27 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Guanine anchoring: a strategy for specific targeting of a G-quadruplex using short PNA, LNA and DNA molecules

D. J. Y. Tan, P. Das, F. R. Winnerdy, K. W. Lim and A. T. Phan, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01778G

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