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An activity-based two-photon fluorescent probe for real-time and reversible imaging of oxidative stress in the rat brain

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Abstract

The real-time and reversible detection of cellular glutathione and oxidative stress challenges the study of the redox homeostasis of biological systems. We report herein a modular approach to design the Michael addition between glutathione and coumarin derivatives for fluorescence imaging of the reversible and dynamic change of oxidative stress in living cells and the rat brain.

Graphical abstract: An activity-based two-photon fluorescent probe for real-time and reversible imaging of oxidative stress in the rat brain

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Article information


Submitted
06 Mar 2020
Accepted
26 Apr 2020
First published
27 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

An activity-based two-photon fluorescent probe for real-time and reversible imaging of oxidative stress in the rat brain

C. Liang, X. Chen, Q. Tang, W. Ji, Y. Jiang, L. Mao and M. Wang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01747G

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