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Iridium-catalyzed C–H amidation of s-tetrazines

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Abstract

An efficient, selective and scalable C–H amidation of s-tetrazines under iridium(III) catalysis is reported. This reaction features a broad substrate scope, high functional group tolerance, and air and water tolerance. This reaction also shows great potential for the rapid preparation of tri- and tetra-functional building blocks, which can be applied either in bioconjugation or synthesis of DNA-encoded library.

Graphical abstract: Iridium-catalyzed C–H amidation of s-tetrazines

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Article information


Submitted
03 Mar 2020
Accepted
16 Mar 2020
First published
17 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Iridium-catalyzed C–H amidation of s-tetrazines

H. Xiong, Y. Gu, S. Zhang, F. Lu, Q. Ji, L. Liu, P. Ma, G. Yang, W. Hou and H. Xu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01647K

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