Issue 58, 2020
From the journal:

Chemical Communications

Imaging of peroxynitrite in drug-induced acute kidney injury with a near-infrared fluorescence and photoacoustic dual-modal molecular probe†

Hong-Wen Liu, ORCID logo a   Haiyang Zhang,a   Xiaofeng Lou,a   Lili Teng,a   Jie Yuan,a   Lin Yuan, ORCID logo a   Xiao-Bing Zhang ORCID logo *a  and  Weihong Tan ORCID logo a  

* Corresponding authors

a Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
E-mail: xbzhang@hnu.edu.cn

Abstract

A FRET-based probe for mapping the fluctuation of ONOO− in cisplatin-induced acute kidney injury was constructed. It exhibits ratiometric near infrared fluorescence and a dramatic decrease of its peak absorbance at 719 nm upon addition of ONOO− that is converted into remarkable signal changes in fluorescence and photoacoustic images respectively.

Graphical abstract: Imaging of peroxynitrite in drug-induced acute kidney injury with a near-infrared fluorescence and photoacoustic dual-modal molecular probe

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Article information

DOI
https://doi.org/10.1039/D0CC01621G
Article type
Communication
Submitted
02 Mar 2020
Accepted
04 Jun 2020
First published
05 Jun 2020

Chem. Commun., 2020,56, 8103-8106

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Imaging of peroxynitrite in drug-induced acute kidney injury with a near-infrared fluorescence and photoacoustic dual-modal molecular probe

H. Liu, H. Zhang, X. Lou, L. Teng, J. Yuan, L. Yuan, X. Zhang and W. Tan, Chem. Commun., 2020, 56, 8103 DOI: 10.1039/D0CC01621G

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