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Imaging of peroxynitrite in drug-induced acute kidney injury with a near-infrared fluorescence and photoacoustic dual-modal molecular probe

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Abstract

A FRET-based probe for mapping the fluctuation of ONOO in cisplatin-induced acute kidney injury was constructed. It exhibits ratiometric near infrared fluorescence and a dramatic decrease of its peak absorbance at 719 nm upon addition of ONOO that is converted into remarkable signal changes in fluorescence and photoacoustic images respectively.

Graphical abstract: Imaging of peroxynitrite in drug-induced acute kidney injury with a near-infrared fluorescence and photoacoustic dual-modal molecular probe

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Article information


Submitted
02 Mar 2020
Accepted
04 Jun 2020
First published
05 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Imaging of peroxynitrite in drug-induced acute kidney injury with a near-infrared fluorescence and photoacoustic dual-modal molecular probe

H. Liu, H. Zhang, X. Lou, L. Teng, J. Yuan, L. Yuan, X. Zhang and W. Tan, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01621G

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