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An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant

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Abstract

An investigation using recombinant ribosomal proteins and synthetic peptide models was conducted to uncover the effect of the introduction of a negative charge at the C-terminal tail of ribosomal protein S15. Our results help provide a chemical rationale towards understanding how G2019S LRRK2, a common clinical mutation, causes Parkinson's disease.

Graphical abstract: An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant

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Article information


Submitted
02 Mar 2020
Accepted
19 Jun 2020
First published
20 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant

D. Correddu, N. Sharma, S. Kaur, K. G. Varnava, N. M. Mbenza, V. Sarojini and I. K. H. Leung, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01618G

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