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A polynuclear Cu(ii) complex for real time monitoring of mitochondrial cytochrome C release during cellular apoptosis

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Abstract

A new amide–imine conjugate, 2-hydroxybenzoic acid-(2-hydroxybenzylidene)-hydrazide (L1), is employed to prepare a single crystal X-ray structurally characterized poly-nuclear Cu(II) complex (M1). M1 selectively and spatially interacts with cytochrome C (Cyt C) to allow fluorescence imaging of intracellular translocation events in living cells. Thus, direct visualization of a Cyt C translocation event during an apoptotic process is achieved for the first time. The binding constant and LOD are 7.52 × 104 M−1 and 34.0 nM, respectively.

Graphical abstract: A polynuclear Cu(ii) complex for real time monitoring of mitochondrial cytochrome C release during cellular apoptosis

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Supplementary files

Article information


Submitted
09 Apr 2020
Accepted
28 Apr 2020
First published
28 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A polynuclear Cu(II) complex for real time monitoring of mitochondrial cytochrome C release during cellular apoptosis

S. Khanra, S. Ta, A. Paladhi, M. Ghosh, S. Ghosh, S. K. Hira, P. P. Manna, P. Brandão, V. Félix and D. Das, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01606C

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