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A biosensor based on multifunctional allostery for dynamic analysis of circulating tumor DNA

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Abstract

Here, a new strategy based on artificial multifunctional allostery (mFA) was explored to regulate the assembly of a DNA nanowire using circulating tumor DNA (ctDNA) as the initiator. Given its unique properties, the mFA-regulated versatile DNA nanowire was applied to engineer a single-step, amplified and dynamic biosensor for the quantitative analysis of ctDNA in serum samples with tunable sensitivity and selectivity.

Graphical abstract: A biosensor based on multifunctional allostery for dynamic analysis of circulating tumor DNA

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Article information


Submitted
28 Feb 2020
Accepted
05 Mar 2020
First published
06 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A biosensor based on multifunctional allostery for dynamic analysis of circulating tumor DNA

X. Lu, L. Wang, Q. Chen, Y. Wang, Z. Cao, G. Zhou and L. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01560A

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