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Selective sensing of THC and related metabolites in biofluids by host:guest arrays

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Abstract

A water-soluble host molecule can bind tetrahydrocannabinol (Δ9-THC) and its metabolites in aqueous solution. By pairing this recognition event in a sensing array with fluorescent reporters and varying external mediators, pattern recognition-based detection is possible, which allows selective discrimination of the THC metabolites. The selective sensing can be performed in aqueous solution with micromolar sensitivity, as well as in biofluids such as urine and saliva. Metabolites as similar as Δ8- and Δ9-THC, differing only in the position of a double bond, can be distinguished.

Graphical abstract: Selective sensing of THC and related metabolites in biofluids by host:guest arrays

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Supplementary files

Article information


Submitted
25 Feb 2020
Accepted
11 Mar 2020
First published
11 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Selective sensing of THC and related metabolites in biofluids by host:guest arrays

A. D. Gill, B. L. Hickey, W. Zhong and R. J. Hooley, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01489C

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