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Synthesis of unsymmetrical ketones by applying visible-light benzophenone/nickel dual catalysis for direct benzylic acylation

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Abstract

Herein, we report a dual catalytic system for the direct benzylic C–H acylation reaction furnishing a variety of unsymmetrical ketones. A benzophenone-derived photosensitizer combined with a nickel catalyst has been established as the catalytic system. Both acid chlorides and anhydrides are able to acylate the benzylic position of toluene and other methylbenzenes. The method offers a valuable alternative to late transition metal catalyzed C–H acylation reactions.

Graphical abstract: Synthesis of unsymmetrical ketones by applying visible-light benzophenone/nickel dual catalysis for direct benzylic acylation

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Article information


Submitted
25 Feb 2020
Accepted
17 Apr 2020
First published
20 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Synthesis of unsymmetrical ketones by applying visible-light benzophenone/nickel dual catalysis for direct benzylic acylation

P. E. Krach, A. Dewanji, T. Yuan and M. Rueping, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01480J

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